İMİDAZOLİNON BAZLI SÜLFONAMİD TÜREVLERİ: SENTEZ, KARAKTERİZASYON VE BAZI METABOLİK ENZİMLERE KARŞI İNHİBİTÖR ÖZELLİKLERİ

Objective: The purpose of the work was to investigate new synthetic compounds imidazolinone-based sulfonamide derivatives as potent and selective enyzme inhibitors. A number synthesized their inhibitory action against acetylcholine esterase (AChE), human (h) carbonic anhydrase (CA) isoforms I II were investigated. Material Method: identity has been confirmed by HRMS, 1H NMR, 13C NMR. pharmacological potential determined in vitro enzyme-based assays. Result Discussion: In this study, a series from 4-(2,4-dimethoxybenzylidene)-2-phenyloxazol-5(4H)-one, sodium acetate, glacial acetic acid, suitable such sulfaguanidine (3), sulfanilamide (4), sulfadiazine (5). These showed II. Compound 4 (Ki=19.53±1.23 nM) inhibitor hCA while compound 3 (Ki=16.49±2.20 found be 5 with Ki 11.68±1.45 nM effect AChE enzyme. Imidazolinone-based sulfonamides can used design CAs inhibitors anti-Alzheimer's for further studies.